Suffering from nervous system disorders, gut imbalance, thyroid dysfunction, insomnia, anxiety, depression, heart problems or addiction? It may be time to find your MTHFR status.

Methylation is a biochemical process that involves the addition of a methyl group to a molecule (CH3). In the context of genetics and molecular biology, methylation commonly refers to the addition of a methyl group to DNA or RNA molecules. Methylation can affect gene expression and it plays a role in about 200 various biological processes.

Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in the methylation cycle; it can limit the methylation that can happen in the body. The MTHFR gene dictates the process for making the enzyme MTHFR. MTHFR is critical for a chemical reaction involving vitamin folate (B9). It enables the conversion of a form of folate called, 5,10-methylenetetrahydrofolate to a different form of folate called methyltetrrahydrofolate (5-MTHFR). This is the main kind of folate found in the bloodstream and is a primary component of the composite process that converts the amino acid homocysteine to another amino acid called methionine. The body uses methionine to make proteins and other important compounds.

The primary role of methylation is to recycle the amino acid homocysteine to keep its levels in a healthy, optimal range. A simple homocysteine blood test can help you understand your own methylation status. High homocysteine levels indicate suboptimal methylation and need attention to decrease the level and to help bring your levels to a healthy range.
Nutrition plays a big role in how smoothly methylation processes run. Taking targeted supplements can support healthy methylation as well as eating foods rich in folate, vitamin B12, vitamin B6, riboflavin, choline, and Coenzyme Q10.

As part of the initial workup with me, you can expect a lab for the MTHFR gene, homocysteine, folate, B12, and many others. Note, if you do have a mutation in the MTHFR gene, it is essential to follow guidelines on treatment throughout your life. It is not something you do for a while and stop. 

Here are some symptoms to watch for if you suspect you may struggle with poor methylation (but of course, get the lab done!): Nervous system issues, gut dysbiosis, thyroid dysfunction, insomnia (especially REM phase), anxiety, depression, heart problems and addiction.
While science is still understanding methylation and other detoxification pathways, it is well understood that poor methylation is beneficial with folate. Should you not know your status on the MTHFR, this would be worthy to have blood drawn.